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About FRAX

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Prof. John A. Kanis University of Sheffield

John A. Kanis is Emeritus Professor in Human Metabolism, and Director of the Centre for Metabolic Bone Diseases (Formerly WHO Collaborating Centre) University of Sheffield, UK and Professorial Fellow at Australian Catholic University (Melbourne, Australia). He is Honorary President of the International Osteoporosis Foundation, member of its Committee of Scientific Advisors and Chairman of the Working Group on Epidemiology and Quality of Life.

Prof. Kanis’s research interests are largely related to disorders of skeletal metabolism including osteoporosis, sarcopenia, Paget’s disease of bone, hyperparathyroidism, renal osteodystrophy and neoplasia affecting the skeleton. Contributions to research include cell biology, histomorphometry of bone, assessment and treatment of bone disorders, guideline development, health technology assessment, epidemiology, regulatory affairs and health economics. He is the Editor in Chief of Osteoporosis International and Archives of Osteoporosis and serves on the editorial board of several journals. He is the author of more than 1000 papers, chapters and books on bone disease and metabolism. His current major interest is in the development of risk assessment algorithms and the formulation of practice guidelines in many regions of the world.

Prof. Eugene McCloskey University of Sheffield

Eugene McCloskey is Professor of Adult Bone Diseases, Mellanby Centre for Musculoskeletal Research, University of Sheffield, and Director of the Medical Research Council Versus Arthritis Centre for Integrated research in Musculoskeletal Ageing. His roles include past President of the Bone Research Society, UK, Chair of the Royal Osteoporosis Society Research Academy Effectiveness Working Group, Board Member of the IOF and ESCEO, and a past member of the ECTS Clinical Practice Action Group. As a member of the National Osteoporosis Guidance Group (NOGG) in the UK, he has helped integrate fracture risk assessment with clinical management. He has published approximately 460 original articles in research areas encompassing the treatment of cancer-associated osteolysis, osteoporosis and Paget’s disease, vertebral fracture definition, non-invasive skeletal assessments and the development of the FRAX® fracture risk assessment tool.

Photo of Eugene Mc Closkey

The FRAX tool was launched in 2008 by a team based within the World Health Organisation (WHO) Collaborating Centre for Metabolic Bone Diseases hosted at the University of Sheffield (1991-2010).  While the FRAX tool is based on data generated from within that centre, FRAX was neither developed or endorsed by WHO and any references to the ‘WHO tool’ are incorrect.

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