CSV Bulk calculations specifications: NPF

This type of CSV allows to get, for each row, adjusted scores according to number of prior fractures.

Prior fractures increase subsequent fracture risk. This adjustment applies the effect of the number of prior fractures on the 10-year probability of fracture determined with FRAX. Note that these adjustments are made in the absence of BMD.

Input Variables

A CSV input file should always have 14 columns. An optional header can be sent as first line of the CSV file:

Score unit,Country,Age,Sex,BMI,Previous fracture,Parental history,Current smoker,Gluccocorticoid,Rheumatoid Arthritis,Secondary osteoporosis,Alcohol,Femoral neck BMD,Number of Previous Fracture

The first columns are the FRAX variables:

#	Col	Variable	Description	Possible Values
1	A	Score unit	Unit for variable 13	t: T-score, z: Z-score. Unit for parameter 13 (BMD) described below.
2	B	Country	Code for country and ethnicity	Integer. Get valid countries' id from the API.
3	C	Age	Age in years	Positive real number (40-90), can have decimals. Out of bound values will be capped.
4	D	Sex	Gender	0: men, 1: women
5	E	BMI	Body Mass Index	Positive real number (kg/m²), can have decimals
6	F	Previous fracture	History of previous fracture	0: no, 1: yes
7	G	Parental history	Parent(s) with hip fracture history	0: no, 1: yes
8	H	Current smoker	Current smoking status	0: no, 1: yes
9	I	Gluccocorticoid	Gluccocorticoid use	0: no, 1: yes
10	J	Rheumatoid Arthritis	Presence of rheumatoid arthritis	0: no, 1: yes
11	K	Secondary osteoporosis	Presence of secondary osteoporosis	0: no, 1: yes
12	L	Alcohol	More than two drinks a day	0: no, 1: yes
13	M	Femoral neck BMD	Bone mineral density measurement	Real number (T-score or Z-score). The T-score for both genders should be derived by comparing the individual BMD to the young normal FEMALE NHANES III reference range for the make of scanner that you are using.

Then we need the adjustment variable:

#	Col	Variable	Description	Possible Values
14	N	Number of Previous Fracture	Number of prior fractures. There's no difference between 4 or more fractures.	Positive integer greater or equal to 1

Output Results

Once processed, you will receive an output file with, for each row, the results append to the original line (the variables above).

#	Col	Result	Description
15	O	NPF MOF wo BMD	Adjusted MOF without BMD according to the number of prior fractures
16	P	NPF Hip wo BMD	Adjusted HIP without BMD according to the number of prior fractures
17	Q	NPF MOF w BMD	Adjusted MOF with BMD according to the number of prior fractures
18	R	NPF Hip w BMD	Adjusted HIP with BMD according to the number of prior fractures

Output warning or error reporting

If an error for any adjustments of the row has been triggered, a specific message will be added at the end of the line.

#	Col	Processor messages
19	S	Warning or error messages