CSV Bulk calculations specifications: PHPT

This type of CSV allows to get, for each row, adjusted scores according to hyperparathyroidism according to age and sex.

Adjusting conventional FRAX estimates of fracture probability in primary hyperparathyroidism according to age and sex, excluding the time after parathyroidectomy (PTX). Note that these adjustments are made in the absence of BMD. There are insufficient data for providing adjustments with input of BMD.

Input Variables

A CSV input file should always have 14 columns. An optional header can be sent as first line of the CSV file:

Score unit,Country,Age,Sex,BMI,Previous fracture,Parental history,Current smoker,Gluccocorticoid,Rheumatoid Arthritis,Secondary osteoporosis,Alcohol,Femoral neck BMD,PHPT without PTX

The first columns are the FRAX variables:

#	Col	Variable	Description	Possible Values
1	A	Score unit	Unit for variable 13	t: T-score, z: Z-score. Unit for parameter 13 (BMD) described below.
2	B	Country	Code for country and ethnicity	Integer. Get valid countries' id from the API.
3	C	Age	Age in years	Positive real number (40-90), can have decimals. Out of bound values will be capped.
4	D	Sex	Gender	0: men, 1: women
5	E	BMI	Body Mass Index	Positive real number (kg/m²), can have decimals
6	F	Previous fracture	History of previous fracture	0: no, 1: yes
7	G	Parental history	Parent(s) with hip fracture history	0: no, 1: yes
8	H	Current smoker	Current smoking status	0: no, 1: yes
9	I	Gluccocorticoid	Gluccocorticoid use	0: no, 1: yes
10	J	Rheumatoid Arthritis	Presence of rheumatoid arthritis	0: no, 1: yes
11	K	Secondary osteoporosis	Presence of secondary osteoporosis	0: no, 1: yes
12	L	Alcohol	More than two drinks a day	0: no, 1: yes
13	M	Femoral neck BMD	Bone mineral density measurement	Real number (T-score or Z-score). The T-score for both genders should be derived by comparing the individual BMD to the young normal FEMALE NHANES III reference range for the make of scanner that you are using.

Then we need the adjustment variable:

#	Col	Variable	Description	Possible Values
14	N	PHPT without PTX	Individual without parathyroidectomy (PTX)	0 Individual without Primary Hyperparathyroidism (PHPT) or individual with PHPT but with parathyroidectomy (PTX): adjustment not possible, 1 Individual with PHPT but without PTX

Output Results

Once processed, you will receive an output file with, for each row, the results append to the original line (the variables above).

#	Col	Result	Description
15	O	FRAX MOF wo BMD	major osteoporotic fracture risk without BMD
16	P	FRAX Hip wo BMD	hip fracture risk without BMD
17	Q	FRAX MOF w BMD	major osteoporotic fracture risk with BMD
18	R	FRAX HIP w BMD	hip fracture risk with BMD
19	S	PHPT MOF wo BMD	Adjusted MOF without BMD according to age and sex
20	T	PHPT Hip wo BMD	Adjusted HIP without BMD according to age and sex
21	U	PHPT MOF w BMD	Adjusted MOF with BMD according to age and sex
22	V	PHPT Hip w BMD	Adjusted HIP with BMD according to age and sex

Output warning or error reporting

If an error for any adjustments of the row has been triggered, a specific message will be added at the end of the line.

#	Col	Processor messages
23	W	Warning or error messages