CSV Bulk calculations specifications: FNLS

This type of CSV allows to get, for each row, adjusted scores according to differences between femoral neck and lumbar spine BMD T-scores.

Adjust major osteoporotic fracture probability according to differences between femoral neck and lumbar spine BMD T-scores. These adjustments have been derived from a study using GE Lunar equipment. Given a high correlation between T-scores derived by GE Lunar and Hologic equipment, the adjustment is probably equally applicable across these two manufacturers. Vertebral levels affected by artifact should be excluded from the LS scans using conventional criteria. Where the lumbar spine is not considered clinically usable even with exclusions, this adjustment should not be undertaken.

Input Variables

A CSV input file should always have 14 columns. An optional header can be sent as first line of the CSV file:

Score unit,Country,Age,Sex,BMI,Previous fracture,Parental history,Current smoker,Gluccocorticoid,Rheumatoid Arthritis,Secondary osteoporosis,Alcohol,Femoral neck BMD,T score

The first columns are the FRAX variables:

#	Col	Variable	Description	Possible Values
1	A	Score unit	Unit for variable 13	t: T-score, z: Z-score. Unit for parameter 13 (BMD) described below.
2	B	Country	Code for country and ethnicity	Integer. Get valid countries' id from the API.
3	C	Age	Age in years	Positive real number (40-90), can have decimals. Out of bound values will be capped.
4	D	Sex	Gender	0: men, 1: women
5	E	BMI	Body Mass Index	Positive real number (kg/m²), can have decimals
6	F	Previous fracture	History of previous fracture	0: no, 1: yes
7	G	Parental history	Parent(s) with hip fracture history	0: no, 1: yes
8	H	Current smoker	Current smoking status	0: no, 1: yes
9	I	Gluccocorticoid	Gluccocorticoid use	0: no, 1: yes
10	J	Rheumatoid Arthritis	Presence of rheumatoid arthritis	0: no, 1: yes
11	K	Secondary osteoporosis	Presence of secondary osteoporosis	0: no, 1: yes
12	L	Alcohol	More than two drinks a day	0: no, 1: yes
13	M	Femoral neck BMD	Bone mineral density measurement	Real number (T-score or Z-score). The T-score for both genders should be derived by comparing the individual BMD to the young normal FEMALE NHANES III reference range for the make of scanner that you are using.

Then we need the adjustment variable:

#	Col	Variable	Description	Possible Values
14	N	T score	Lumbar spine BMD T-score	Real number

Output Results

Once processed, you will receive an output file with, for each row, the results append to the original line (the variables above).

#	Col	Result	Description
15	O	FNLS MOF w BMD	Adjusted MOF with BMD based on FN-LS discordance (if LS is given)
16	P	FNLS Hip w BMD	Adjusted HIP with BMD based on FN-LS discordance (if LS is given)

Output warning or error reporting

If an error for any adjustments of the row has been triggered, a specific message will be added at the end of the line.

#	Col	Processor messages
17	Q	Warning or error messages